Cell type gene expression markers


This is a list of gene expression markers are used to define cell types. Green rows indicate canonical markers (classical markers used to define the cell type).

Summary: 8286 associations (178 cell types, 4679 gene symbols, 29 tissues); Last updated: 27/03/2020 10:44:00 CET

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Description: Alpha cells are endocrine cells in the pancreatic islets of the pancreas. They make up to 20% of the human islet cells synthesizing and secreting the peptide hormone glucagon, which elevates the glucose levels in the blood.

Gene expression markers for Alpha cells

Vote(s) Species Official gene symbol UI Sensitivity (human) Sensitivity (mouse) Specificity (human) Specificity (mouse) Marker count Cell type Germ layer Organ Aliases Product description Disease Action
1
Mm Hs GCG 0.024 0.839 0.75 0.044 0.018 2 Alpha cells Endoderm Pancreas GLP2,GRPP glucagon flag
1
Mm Hs FXYD5 0.213 0.742 NA 0.375 0.174 1 Alpha cells Endoderm Pancreas OIT2 FXYD domain containing ion transport regulator 5 flag
1
Mm Hs MAFB 0.053 0.71 0.7 0.053 0.051 6 Alpha cells Endoderm Pancreas KRML MAF bZIP transcription factor B Yflag
1
Mm Hs PCSK2 0.032 0.839 0.85 0.017 0.033 4 Alpha cells Endoderm Pancreas SPC2,NEC2 proprotein convertase subtilisin/kexin type 2 flag
1
Mm Hs CHGA 0.057 0.968 1 0.029 0.06 6 Alpha cells Endoderm Pancreas chromogranin A flag
0
Mm Hs KLHL41 0.001 0.032 NA 0 0.001 1 Alpha cells Endoderm Pancreas SARCOSIN,Krp1,KBTBD10 kelch like family member 41 Yflag
0
Hs SCGB2A1 0.003 0.806 NA 0.01 NA 3 Alpha cells Endoderm Pancreas UGB3,LPHC,MGC71973,MGB2 secretoglobin family 2A member 1 flag
0
Mm Hs FAP 0.006 NA NA 0.003 0.007 4 Alpha cells Endoderm Pancreas fibroblast activation protein alpha flag
0
Mm Hs DPP4 0.02 NA NA 0.013 0.021 9 Alpha cells Endoderm Pancreas CD26,ADCP2 dipeptidyl peptidase 4 flag
0
Mm Hs GPR119 0 NA 0.1 NA 0 2 Alpha cells Endoderm Pancreas hGPCR2,GPCR2 G protein-coupled receptor 119 flag
0
Mm Hs PAX6 0.049 0.258 0.85 0.012 0.057 8 Alpha cells Endoderm Pancreas D11S812E,AN2 paired box 6 Yflag
0
Mm Hs NEUROD1 0.038 0.806 1 0.016 0.041 8 Alpha cells Endoderm Pancreas BETA2,BHF-1,NeuroD,bHLHa3,MODY6,NEUROD neuronal differentiation 1 Yflag
0
Mm Hs LOXL4 0 0.129 NA NA 0 1 Alpha cells Endoderm Pancreas FLJ21889,LOXC lysyl oxidase like 4 flag
0
Mm Hs PLCE1 0.005 0.032 NA 0.008 0.005 3 Alpha cells Endoderm Pancreas KIAA1516,NPHS3 phospholipase C epsilon 1 Yflag
0
Mm Hs GC 0.009 0.774 0.375 0.007 0.007 3 Alpha cells Endoderm Pancreas VDBP,hDBP GC, vitamin D binding protein flag
0
Mm Hs SLC30A8 0.005 0.677 NA 0.009 NA 2 Alpha cells Endoderm Pancreas ZnT-8 solute carrier family 30 member 8 Yflag
0
Mm Hs FEV 0.003 0.161 0.475 0.002 0.002 2 Alpha cells Endoderm Pancreas Pet-1 FEV, ETS transcription factor flag
0
Mm Hs PTGER3 0.001 NA NA 0.001 0.001 1 Alpha cells Endoderm Pancreas EP3 prostaglandin E receptor 3 flag
0
Mm Hs RFX6 0.001 0.226 NA 0.001 NA 1 Alpha cells Endoderm Pancreas MGC33442,dJ955L16.1,RFXDC1 regulatory factor X6 Yflag
0
Mm Hs SMARCA1 0.015 0.097 NA 0.041 NA 3 Alpha cells Endoderm Pancreas NURF140,SWI,hSNF2L,SNF2L1,SNF2L SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 flag
0
Mm Hs PGR 0.003 NA NA 0.007 0.002 3 Alpha cells Endoderm Pancreas NR3C3 progesterone receptor Yflag
0
Mm Hs LDB2 0.019 NA NA 0.025 0.019 1 Alpha cells Endoderm Pancreas LDB1 LIM domain binding 2 flag
0
Mm Hs IRX1 0.009 NA 0.125 NA 0.011 2 Alpha cells Endoderm Pancreas IRX-5 iroquois homeobox 1 flag
0
Mm Hs UCP2 0.013 0.161 NA 0.003 NA 8 Alpha cells Endoderm Pancreas SLC25A8,BMIQ4 uncoupling protein 2 Yflag
0
Mm Hs RGS4 0.052 0.387 NA 0.006 NA 1 Alpha cells Endoderm Pancreas SCZD9 regulator of G protein signaling 4 flag
0
Mm Hs GLS 0.061 0.097 0.25 0.019 0.072 4 Alpha cells Endoderm Pancreas KIAA0838,GLS1 glutaminase flag
0
Mm Hs NKX6-1 0.006 0.032 0.3 0.01 0.005 4 Alpha cells Endoderm Pancreas Nkx6.1,NKX6A NK6 homeobox 1 flag
0
Mm Hs TTR 0.055 0.839 NA 0.066 NA 4 Alpha cells Endoderm Pancreas HsT2651,CTS,PALB,CTS1 transthyretin Yflag
0
Mm Hs GLP1R 0 NA NA NA 0 2 Alpha cells Endoderm Pancreas GLP-1R glucagon like peptide 1 receptor flag
0
Mm Hs ARX 0.019 0.129 0.35 0.001 0.023 7 Alpha cells Endoderm Pancreas ISSX,CT121,EIEE1,MRXS1,PRTS,MRX76,MRX54,MRX43,MRX36,MRX29,MRX32,MRX33,MRX38,MRX87 aristaless related homeobox Yflag
0
Mm Hs POU3F4 0.004 NA 0.275 0.002 0.004 2 Alpha cells Endoderm Pancreas BRN4,OTF9,DFNX2,DFN3 POU class 3 homeobox 4 Yflag
0
Mm Hs NKX2-2 0.002 0.29 0.075 0.008 0 6 Alpha cells Endoderm Pancreas NKX2.2,NKX2B NK2 homeobox 2 flag
0
Mm Hs RESP18 0.062 NA NA NA NA 3 Alpha cells Endoderm Pancreas regulated endocrine specific protein 18 flag
0
Mm Hs PYY 0.016 NA 0.925 0.001 0.018 2 Alpha cells Endoderm Pancreas PYY1 peptide YY flag
0
Mm Hs SLC38A5 0.02 NA NA 0.023 NA 3 Alpha cells Endoderm Pancreas SN2,JM24 solute carrier family 38 member 5 flag
0
Mm Hs TM4SF4 0.017 0.806 NA 0.013 NA 3 Alpha cells Endoderm Pancreas il-TMP transmembrane 4 L six family member 4 flag
0
Mm Hs CRYBA2 0.009 0.968 0.975 0.011 0.005 1 Alpha cells Endoderm Pancreas crystallin beta A2 Yflag
0
Mm Hs SH3GL2 0.025 0.032 NA 0.002 NA 2 Alpha cells Endoderm Pancreas SH3P4,SH3D2A,CNSA2,EEN-B1 SH3 domain containing GRB2 like 2, endophilin A1 flag
0
Mm Hs KCNK16 0.007 0.226 0.875 0.006 0.004 2 Alpha cells Endoderm Pancreas K2p16.1,TALK-1,TALK1 potassium two pore domain channel subfamily K member 16 flag
0
Mm Hs PCSK1 0.008 0.065 0.225 0.009 0.008 5 Alpha cells Endoderm Pancreas PC1,NEC1 proprotein convertase subtilisin/kexin type 1 Yflag
0
Mm Hs PRRG2 0.009 0.065 0.475 0 0.01 1 Alpha cells Endoderm Pancreas PRGP2 proline rich and Gla domain 2 flag
0
Mm Hs IRX2 0.012 0.097 0.275 0.005 0.012 2 Alpha cells Endoderm Pancreas iroquois homeobox 2 flag
0
Mm Hs ALDH1A1 0.039 0.903 NA 0.08 0.029 5 Alpha cells Endoderm Pancreas RALDH1,PUMB1,ALDH1 aldehyde dehydrogenase 1 family member A1 flag
0
Mm Hs PEMT 0.013 0.71 NA 0.039 0.003 1 Alpha cells Endoderm Pancreas PEMPT,PEMT2 phosphatidylethanolamine N-methyltransferase flag
0
Mm Hs SMIM24 0.037 0.742 NA 0.028 NA 2 Alpha cells Endoderm Pancreas HSPC323,C19orf77 small integral membrane protein 24 flag
0
Mm Hs F10 0.011 0.645 NA 0.009 0.008 1 Alpha cells Endoderm Pancreas coagulation factor X Yflag
0
Mm Hs SCGN 0.014 0.839 NA 0.022 NA 6 Alpha cells Endoderm Pancreas SECRET,DJ501N12.8,SEGN,CALBL secretagogin, EF-hand calcium binding protein flag
-1
4 DEPP1 0 NA NA NA NA 1 Alpha cells Endoderm Pancreas DEPP,Fseg,C10orf10 DEPP1, autophagy regulator flag

Datasets with computationally identified Alpha cells

SRA SRS tissue cluster cell type p-value FDR View
SRA701877 SRS3279684 Pancreatic islets 1 Alpha cells 2.91E-10 1.02E-7 view data
SRA701877 SRS3279684 Pancreatic islets 2 Alpha cells 1.93E-11 1.19E-8 view data
SRA701877 SRS3279684 Pancreatic islets 3 Alpha cells 1.64E-11 1.19E-8 view data
SRA701877 SRS3279694 Pancreatic islets 0 Alpha cells 2.28E-11 2.41E-8 view data
SRA701877 SRS3279694 Pancreatic islets 8 Alpha cells 6.84E-11 4.81E-8 view data
SRA701877 SRS3279694 Pancreatic islets 10 Alpha cells 4.45E-5 7.24E-3 view data
SRA585365 SRS2345688 Pancreas 9 Alpha cells 1.01E-6 9.57E-4 view data
SRA701877 SRS3279692 Pancreatic islets 3 Alpha cells 1.90E-10 8.21E-8 view data
SRA701877 SRS3279685 Pancreatic islets 1 Alpha cells 5.06E-10 2.04E-7 view data
SRA745567 SRS3600294 Pancreatic islets 4 Alpha cells 5.55E-6 1.70E-3 view data
SRA745567 SRS3600294 Pancreatic islets 8 Alpha cells 4.46E-7 1.88E-4 view data
SRA585365 SRS2345686 Pancreas 7 Alpha cells 7.39E-8 1.38E-4 view data
SRA745567 SRS3600300 Pancreatic islets 1 Alpha cells 1.14E-8 1.58E-6 view data
SRA745567 SRS3600300 Pancreatic islets 16 Alpha cells 4.83E-7 5.37E-5 view data
SRA745567 SRS3600297 Pancreatic islets 3 Alpha cells 5.90E-8 2.26E-5 view data
SRA701877 SRS3279686 Pancreatic islets 0 Alpha cells 7.15E-12 4.43E-9 view data
SRA701877 SRS3279686 Pancreatic islets 4 Alpha cells 3.96E-6 8.18E-4 view data
SRA745567 SRS3600295 Pancreatic islets 6 Alpha cells 8.07E-8 3.88E-5 view data
SRA585365 SRS3297652 Pancreas 8 Alpha cells 1.28E-7 5.08E-5 view data
SRA701877 SRS3279691 Pancreatic islets 0 Alpha cells 1.86E-12 8.56E-10 view data
SRA701877 SRS3279691 Pancreatic islets 12 Alpha cells 4.44E-9 1.46E-6 view data
SRA585365 SRS3297653 Pancreas 1 Alpha cells 2.36E-10 1.93E-7 view data
SRA585365 SRS3297653 Pancreas 4 Alpha cells 1.78E-11 3.99E-8 view data
SRA585365 SRS3297653 Pancreas 5 Alpha cells 1.10E-8 5.60E-6 view data
SRA585365 SRS3297653 Pancreas 12 Alpha cells 1.95E-11 3.99E-8 view data
SRA653146 SRS2874280 Pancreas 1 Alpha cells 5.38E-12 1.07E-9 view data
SRA653146 SRS2874280 Pancreas 2 Alpha cells 6.26E-9 7.12E-7 view data
SRA653146 SRS2874280 Pancreas 10 Alpha cells 2.68E-7 2.51E-5 view data
SRA585365 SRS2345685 Pancreas 4 Alpha cells 7.98E-10 5.68E-7 view data
SRA745567 SRS3600299 Pancreatic islets 0 Alpha cells 3.95E-9 6.43E-7 view data
SRA745567 SRS3600299 Pancreatic islets 9 Alpha cells 3.93E-9 6.43E-7 view data
SRA745567 SRS3600299 Pancreatic islets 10 Alpha cells 3.67E-8 4.99E-6 view data
SRA585365 SRS2345687 Pancreas 7 Alpha cells 3.85E-10 4.09E-7 view data
SRA745567 SRS3600301 Pancreatic islets 4 Alpha cells 2.78E-9 3.67E-7 view data
SRA784304 SRS3823097 Pancreatic progenitor cells 0 Alpha cells 6.78E-9 1.60E-6 view data
SRA784304 SRS3823097 Pancreatic progenitor cells 13 Alpha cells 2.18E-6 1.89E-4 view data
SRA823298 SRS4144446 Alpha cells 1 Alpha cells 3.17E-11 8.04E-9 view data
SRA823298 SRS4144446 Alpha cells 2 Alpha cells 2.55E-11 8.04E-9 view data
SRA585365 SRS3297650 Pancreas 6 Alpha cells 1.22E-8 1.05E-5 view data
SRA585365 SRS3297650 Pancreas 13 Alpha cells 1.58E-7 1.16E-4 view data
SRA585365 SRS3297650 Pancreas 18 Alpha cells 1.69E-4 4.86E-2 view data
SRA745567 SRS3600298 Pancreatic islets 2 Alpha cells 2.27E-8 8.02E-6 view data
SRA823298 SRS4144448 Alpha cells 2 Alpha cells 6.98E-11 8.70E-8 view data
SRA823298 SRS4144448 Alpha cells 3 Alpha cells 2.45E-10 1.53E-7 view data
SRA823298 SRS4144448 Alpha cells 4 Alpha cells 1.32E-7 4.12E-5 view data
SRA823298 SRS4144448 Alpha cells 5 Alpha cells 1.43E-8 5.95E-6 view data
SRA701877 SRS3279688 Pancreatic islets 0 Alpha cells 4.88E-10 5.15E-7 view data
SRA585365 SRS3297649 Pancreas 13 Alpha cells 1.50E-7 1.86E-4 view data
SRA585365 SRS3297649 Pancreas 20 Alpha cells 4.23E-9 7.03E-6 view data
SRA784304 SRS3823096 Pancreatic progenitor cells 0 Alpha cells 3.21E-8 1.02E-5 view data
SRA784304 SRS3823096 Pancreatic progenitor cells 2 Alpha cells 3.47E-9 1.61E-6 view data
SRA784304 SRS3823096 Pancreatic progenitor cells 4 Alpha cells 5.13E-8 1.29E-5 view data
SRA745567 SRS3600296 Pancreatic islets 1 Alpha cells 1.50E-6 5.74E-4 view data
SRA628138 SRS2659225 Intestinal organoid epithelial cells 9 Alpha cells 3.36E-6 5.29E-4 view data
SRA585365 SRS3297651 Pancreas 11 Alpha cells 1.55E-9 6.78E-7 view data
SRA585365 SRS3297654 Pancreas 2 Alpha cells 2.19E-10 1.87E-7 view data
SRA585365 SRS3297654 Pancreas 4 Alpha cells 1.29E-12 5.51E-9 view data
SRA585365 SRS3297654 Pancreas 5 Alpha cells 2.05E-8 9.74E-6 view data
SRA701877 SRS3279687 Pancreatic islets 1 Alpha cells 1.19E-9 5.47E-7 view data
SRA701877 SRS3279687 Pancreatic islets 12 Alpha cells 1.99E-9 7.57E-7 view data
SRA745567 SRS3600293 Pancreatic islets 5 Alpha cells 1.14E-5 3.47E-3 view data
SRA701877 SRS3279689 Pancreatic islets 0 Alpha cells 2.13E-11 1.27E-8 view data
SRA701877 SRS3279695 Pancreatic islets 1 Alpha cells 2.85E-10 1.64E-7 view data
SRA784304 SRS3823100 Pancreatic progenitor cells 0 Alpha cells 6.46E-9 6.90E-6 view data
SRA784304 SRS3823100 Pancreatic progenitor cells 1 Alpha cells 4.07E-7 2.18E-4 view data
SRA784304 SRS3823100 Pancreatic progenitor cells 2 Alpha cells 1.69E-4 3.01E-2 view data
SRA784304 SRS3823100 Pancreatic progenitor cells 3 Alpha cells 1.17E-9 2.50E-6 view data
SRA784304 SRS3823100 Pancreatic progenitor cells 6 Alpha cells 9.47E-7 3.45E-4 view data
SRA701877 SRS3279690 Pancreatic islets 1 Alpha cells 3.15E-10 1.78E-7 view data
SRA701877 SRS3279693 Pancreatic islets 0 Alpha cells 4.25E-11 2.84E-8 view data
SRA701877 SRS3279693 Pancreatic islets 11 Alpha cells 2.62E-8 1.00E-5 view data